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Optimization of Microemulsion Based Transdermal Gel of Triamcinolone

Author(s):

Swati Jagdale and Bhagyashree Chaudhari   Pages 1 - 18 ( 18 )

Abstract:


Background: Triamcinolone is a long acting corticosteroid used in the treatment of arthritis, eczema, psoriasis and similar conditions which causes inflammation. Triamcinolone has half-life of 88 minutes. Prolonged oral use is associated with gastrointestinal adverse effects as peptic ulcer, abdominal distention and ulcerative esophagitis. Microemulgel offers advantage of better stability, better loading capacity and controlled release especially for drug with short half life. Objective: Objective of the present study was to optimize microemulgel based transdermal delivery of triamcinolone. Method: Saturated solubility of triamcinolone in various oils, surfactants and co-surfactants is estimated. Pseudo-ternary phase diagrams were constructed to determine the region of transparent microemulsion. Microemulsion was evaluated for globule size (FE-SEM, zetasizer), % transmittance, pH, viscosity, conductivity etc. Design of experiment was used to optimize microemulsion based gel. Carbopol 971P and HPMC K100M were used as independent variable. Microemulsion based gel were evaluated for in-vitro as well as ex-vivo parameters. Results: Microemulsion was formulated with oleic acid, lauroglycol FCC and propylene glycol. PDI 0.197 indicated microemulsion is mono-disperse. 32 factorial design gave batch F8 as optimized. Design expert suggested drug release; gel viscosity and bio-adhesive strength were three significant dependant factors affecting the transdermal delivery. F8 showed drug release 92.62.16±1.22 % through egg membrane, 95.23±1.44% through goat skin after 8 hrs and followed Korsmeyer-Peppas release model. Conclusion: It can be concluded that a stable, effective controlled release transdermal microemulgel was optimised for triamcinolone. This would be a promising tool to deliver triamcinolone with enhanced bioavailability and reduced dosing frequency.

Keywords:

Triamcinolone, arthritis, microemulsion, gel, delivery, optimization

Affiliation:

Department of Pharmaceutics, MAEER`s Maharashtra Institute of Pharmacy, MIT Campus, Pune, (MS), 411038, Maeer`s Maharashra Institute Of Pharmacy,S.No124, Mit Campus,Kothrud,Pune-411038,India,Maharashtra - Pharmaceutics Pune, India Pharmaceutics Pune



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