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Nano-carriers for the Treatment of Tuberculosis

Author(s):

Syed Sarim Imam, Sadaf Jamal Gilani, Abdul Hafeez and Mahfoozur Rahman   Pages 1 - 12 ( 12 )

Abstract:


Background: Nanotechnology is an emerging science with the potential to create new materials and strategies involving manipulation of matter at the nanometer scale. Colloidal drug delivery systems have been extensively investigated as drug carriers for the application of different anti tubercular drugs.

Methods: The different delivery systems like solid lipid nanoparticles and polymeric nanoparticles have been investigated for a long time to treat diseases. There are number of drawbacks in conventional TB dosage forms are the development of multiple drug resistance, resulting intolerable toxicity and high dose requirements. So overcome the drawbacks of conventional therapy, there is a need of a new delivery with the aim of minimizing the side effects of drug therapy. Nanoparticle based drug delivery systems have considerable potential for treatment of TB. This delivery system having several advantages like high stability, high loading capacity, feasibility of incorporation of both hydrophilic and hydrophobic drugs, and feasibility of variable routes of administration, and prolonged release from the matrix. These advantages of nanoparticles enable improvement of drug solubility, bioavailability, reduction of the dosing frequency, high targeting, and may resolve the problem of nonadherence to prescribed therapy, which is one of the major obstacles in the control of TB epidemics.

Conclusion: This review gives an exhaustive review on patents and research papers published over the years in the area of challenges with the current treatment therapy of the disease and potential advantages of nanotechnology to provide more effective treatment and prevention for TB.

Keywords:

Tuberculosis, Nanotechnology, Polymeric nanoparticle, Antitubercular drugs, Immunization

Affiliation:

Glocal School of Pharmacy, The Glocal University, Saharanpur, Uttar Pradesh, Glocal School of Pharmacy, The Glocal University, Saharanpur, Uttar Pradesh, Glocal School of Pharmacy, The Glocal University, Saharanpur, Uttar Pradesh, Abhilashi College of Pharmacy, Tanda, Mandi, Ner Chowk, Himachal Pradesh



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