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Nanoemulsion-Based Transdermal Drug Delivery System for the Treatment of Tuberculosis

[ Vol. 12 , Issue. 2 ]

Author(s):

Mohammad Wais*, Mohammad Aqil, Priyanka Goswami, Jaya Agnihotri and Sayyed Nadeem   Pages 107 - 119 ( 13 )

Abstract:


Background: The nanoemulsion based carriers are the most suitable delivery systems for poorly soluble drugs to improve the drugs solubility, permeation of drugs and ultimately increase bioavailability by transdermal therapeutic system. The nanoemulsion for poorly soluble drugs is admirable and offered several advantages over others drug delivery.

Methods: For nanoemulsions formulation, they have to deliver the energetic element at the specific organ with nominal uneasiness. Because of the prevention of hepatic first pass uptake transdermal course excel usual crest and trough plasma shape that usually comfort the administration. The antitubercular drugs relate to the formulation of Poly DL-Lactide-Co-Glycolide nanoparticles having an active substance encapsulated within and that the encapsulated substances are stable with respect to each other.

Conclusion: The present study aimed to explore the challenges and methods in order to increase the solubility of poorly aqueous soluble drug for improved bioavailability alongwith relative study of toxicity problems related to anti-tubercular drug.

Keywords:

Nanoemulsion, anti-tubercular drugs, infections, permeability, stratum corneum, tuberculosis.

Affiliation:

H.K. College of Pharmacy, H.K. Building, Partiksha Nagar Relief Road, Oshiwara, Jogeshwari (W), Mumbai-400102, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-62, H.K. College of Pharmacy, H.K. Building, Partiksha Nagar Relief Road, Oshiwara, Jogeshwari (W), Mumbai-400102, H.K. College of Pharmacy, H.K. Building, Partiksha Nagar Relief Road, Oshiwara, Jogeshwari (W), Mumbai-400102, H.K. College of Pharmacy, H.K. Building, Partiksha Nagar Relief Road, Oshiwara, Jogeshwari (W), Mumbai-400102

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