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New Drugs and Vaccines for Tuberculosis

[ Vol. 12 , Issue. 2 ]

Author(s):

Praveen K. Gaur* and Shikha Mishra   Pages 147 - 161 ( 15 )

Abstract:


Background: Tuberculosis (TB) is an infectious disease that resulted in estimated 9.6 million new cases in 2014 and 1.5 million deaths. The available drug regimen for TB is time consuming which more often leads to the patient non compliance which then results in occurrence of drug resistant TB (Multi-drug and extremely drug resistant TB) in several portions of the world.

Methods: The dangerous combinations of TB and HIV is taking its toll on human health. The foremost factor is non- profit associated with the development of anti TB drugs. There is almost 10 different drugs in various levels of trials whereas the vaccine development is focusing more on adult vaccine rather than a child vaccine.

Results: More than 15 vaccine candidate are in various stages of pipelines. Present compilation gives an account for various drug candidates and vaccine products in various stages of drug development. Also included is a recent collection of patents for assay methods, potential drug candidates/classes and vaccination products.

Conclusion: The need is for improvement in the activity and chemical and biological description of under development compounds. Lastly the set up for clinical and appropriate uses for running a reliable clinical trial is a necessary prerequisite.

Keywords:

XDR, MDR, vaccine, HIV-TB burden, tuberculosis, patent.

Affiliation:

Department of Pharmaceutics, I.T.S College of Pharmacy, Delhi-Meerut Road, Murad Nagar, Ghaziabad-201206, Department of Pharmaceutical Chemistry, I.T.S College of Pharmacy, Delhi-Meerut Road, Murad Nagar, Ghaziabad-201206

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