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Macrophage Targeted Cellular Carriers for Effective Delivery of Anti-Tubercular Drugs

[ Vol. 12 , Issue. 2 ]

Author(s):

Jaya Agnihotri, Sobhna Singh, Mohammad Wais and Abhishek Pathak*   Pages 162 - 183 ( 22 )

Abstract:


Background: Newly developed vaccine VPM1002 confers paradigm swing in the prophylactic treatment of tuberculosis (TB). Multi-drug resistant and latent TB in adults as well as in underprivileged patients is instigating menace over world population if the host is immune-compromised.

Methods: One third of the world’s population is infected with TB. Recently it is estimated around 9.6 million people around the world became sick with TB disease. There were 1.5 million TB-related deaths worldwide. Therefore with the advent in biotechnology and Nano engineering, newly adapted survival molecular mechanism of Mycobacterium tuberculosis, new targets receptors on alveolar macrophages must be explored out for eradication of TB from the globe. Macrophage acts as a reservoir of phagocytic receptors to execute diverse physiological functions as well as to perform defense mechanism.

Results: Advances in novel carriers open new era for the treatment of tuberculosis which remains a very substantial global health encumbrance. Different binding receptors especially mannose, folate and scavenger receptors are attractive platform for internalization of therapeutics in alveolar macrophage. Nano-carriers and nano-devices designed after the acquaintance of receptor composition and functioning affords site specific targeting of biodegradable and biocompatible drug delivery systems for the treatment of tuberculosis offering complete cure and patient compliance.

Conclusion: This chapter encompasses recent studies on nanocarriers and new treatment strategies for tuberculosis. In spite of the budding benefits of nano carriers, many limitations still remain to be overcome such as poor oral stability, instability in circulation, inadequate tissue distribution as well as toxicity to normal cells.

Keywords:

Tuberculosis, phagolysosome, macrophages, platelets, exertion, thiacetazone.

Affiliation:

H K College of Pharmacy, Jogeshwari (w), Mumbai, Department of Pharmacy, M.J.P. Rohilkhand University, Bareilly, UP, H K College of Pharmacy, Jogeshwari (w), Mumbai, DM IMS, BHU, Varanasi, Uttar Pradesh, 221005

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